BDBM50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound)
SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
InChI Key InChIKey=CVWXJKQAOSCOAB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 75 hits for monomerid = 50300690
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 72nMAssay Description:FLT3 is a receptor tyrosine kinase involved in survival and proliferation of leukemic cells. Constitutively activating FLT3 mutations has been found ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 120nMAssay Description:Inhibition of FLT3 kinase (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.60nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.60nMAssay Description:Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 7.10nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 8.80nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 2.20nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.30nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 3.70nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 5.10nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 137nMAssay Description:Inhibition of human FLT D835Y mutant using 10 uM ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 120nMAssay Description:Inhibition of human FLT3 using 10 uM ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 39nMAssay Description:Inhibition of FLT3 (unknown origin) using FAM-EPLYWSFPA as substrate preincubated for 60 mins followed by substrate addition by microfluidics assay i...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type GST-tagged FLT3 kinase domain (Y567 to S993) (unknown origin) expressed in baculovirus infected insect Sf9 cells using Her2 p...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 2nMAssay Description:Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 93nMAssay Description:Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.60nMAssay Description:Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 autophosphorylation in human AML cells isolated from relapsed acute myeloid leukemia patient by Western blottingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.60nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 4.10nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human FLT3 expressed in insect Sf21 cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human wild-type FLT3 (564 to end residues) expressed in baculovirus infected sf21 cells using Abltide...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 30nMAssay Description:Inhibition of human HL60 cells-derived His-tagged FLT3 (564 to 993 residues) expressed in baculovirus infected sf9 cells using poly (4:1 Glu, Tyr) as...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 15.9nMAssay Description:In the experiments of in vitro enzymatic activity, the IC50 values of Compound 33, Compound 30, Compound 14, Compound 20, Compound 22, Compound 23, C...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 136nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant wild type human FLT3 (R571 to S993 residues) expressed in Sf9 insect cells using poly (Ala,Glu,Ly...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 170nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: <0.510nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK substrate and [gamma-33P]-ATP by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 8.80nMAssay Description:Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.30nMAssay Description:Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expressionMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 3.70nMAssay Description:Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 8.80nMAssay Description:Binding affinity to FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 3.70nMAssay Description:Binding affinity to FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 7.10nMAssay Description:Binding affinity to FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.30nMAssay Description:Binding affinity to wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FLT3 (unknown origin) (592 to 969 residues)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged FLT3 ITD mutant (571 to 993 residues) expressed in Sf9 cells using Tyr2 peptide as substra...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 1.30nMAssay Description:Binding affinity to recombinant human FLT3 (592 to 969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 3.60nMAssay Description:Binding affinity to recombinant human FLT3 ITD mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 420nMAssay Description:Binding affinity to recombinant human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech
US Patent
Shanghai De Novo Pharmatech
US Patent
Affinity DataKd: 55nMAssay Description:Binding affinity to recombinant human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair